FK 482, a new orally active cephalosporin. Synthesis and biological properties.
نویسندگان
چکیده
منابع مشابه
New orally active cephalosporin esters.
and 9b, were prepared as reported in the ref3). The other pivaloyloxymethyl esters, 9c, 9d and 9e, were prepared via another procedure, which is shown in Scheme 2. Other esters llp~ llw were prepared in the manner similar to that of 9e from the sodium salt of 5e and the corresponding halides. The latter halides were prepared from chloromethyl chlorosulfate (or chloromethyl iodide) and the corre-
متن کاملStudies on beta-lactam antibiotics. IX. Synthesis and biological activity of a new orally active cephalosporin, cefixime (FK027).
The synthesis and some biological properties of 7 beta-[(Z)-2-(2-amino-4-thiazolyl)-2-(carboxymethoxyimino) acetamido]-3-vinyl-3-cephem-4-carboxylic acid (3, FK027) are described. Diphenylmethyl 7-amino-3-vinyl-3-cephem-4-carboxylate hydrochloride (8), the cephem precursor to FK027 was prepared from 7-aminocephalosporanic acid (7-ACA) by two parallel routes differing primarily in the protection...
متن کاملCGP 9000: a new orally active, broad-spectrum cephalosporin.
CGP 9000, (7-[D-2-amino-2-(1,4-cyclohexadienyl)-acetamido]-3-methoxy-3-cephem-4-carboxylic acid), is a new broad-spectrum cephalosporin antibiotic. Its antibacterial activity in vitro (MIC) is similar, but its bactericidal efficacy superior to that of cephalexin and cephradine. Upon oral administration to mice infected with various bacteria, CGP 9000 is, in general, 2 to 7 times more effective ...
متن کاملMechanism of action of the new orally active cephalosporin FK027.
The mechanism of action of a new orally active cephalosporin, FK027, was compared to that of cephalexin and cefaclor to elucidate its excellent antibacterial activity against Gram-negative bacteria. FK027 showed very high affinity for the penicillin-binding proteins (PBPs) 3, 1a and 1bs of Escherichia coli whereas cephalexin showed fairly high affinity for PBPs 1a, 4 and 3. The ability of FK027...
متن کاملsynthesis and characterization of potentially biological active cyclometallated organoplatinum(ii) complexes
this work is presented in five parts. in the first part preparation of the starting complex [pt(c^n)cl(dmso)], 1, in which c^n = n(1),c(2?)-chelated, deprotonated 2-phenylpyridine, and dmso = dimethylsulfoxide, and its reaction with 1 equiv of the biphosphine ligands bis(diphenylphosphino)amine, dppa, or bis(diphenylphosphino)methane, dppm, to give the complex [pt(c^n)cl(dppa)], 2, or [pt(c^n)c...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1988
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.41.828